With the hopes of the nation resting on his shoulders, the Scot beat Novak Djokovic 6-4, 7-5, 6-4 on Centre Court.
The Scot, 26, broke down in tears of joy as his triumph sank in before sprinting across the famous lawn to embrace his girlfriend Kim Sears, 25, in the player's box.
Murray won his first grand slam at the US Open last year and was keen to take the title at Wimbledon after losing to Roger Federer in an emotional final last year.
Thousands of people descended on the famous All-England club, including Prime Minister David Cameron, Scotland First Minister Alex Salmond, Victoria Beckham and Wayne Rooney, while millions tuned in to watch the action on television.
On Murray Mount, fans held union flags and Scottish Saltires as they squeezed on to the steep bank to watch the tense tie.
Prime Minister David Cameron, who was in the crowd, led tributes to Murray, tweeting: "It was a privilege to watch @andy--murray making history at #Wimbledon, and making Britain proud."